![]() ![]() Nine of 10 redheads were either homozygous or compound heterozygotes for mutations on the melanocortin-1 receptor gene.Ĭonclusions: Red hair appears to be a distinct phenotype linked to anesthetic requirement in humans that can also be traced to a specific genotype. Results: The desflurane requirement in redheads (6.2 volume-percent ) was significantly greater than in dark-haired women (5.2 volume-percent, P = 0.0004). ![]() ![]() Desflurane requirements in the two groups were compared using Mann-Whitney nonparametric two-sample test P < 0.05 was considered statistically significant. Individual logistic regression curves were used to determine desflurane requirement (P 50). This was continued until volunteers “crossed-over” from movement to non-movement (or vice versa) four times. If the volunteer moved in response to stimulation, desflurane was increased by 0.5% otherwise it was decreased by 0.5%. After an equilibration period, a noxious electrical stimulation (100 Hz, 70 mA) was transmitted through bilateral intradermal needles. Anesthesia was induced with sevoflurane and maintained with desflurane randomly set at an end-tidal concentration between 5.5 and 7.5%. Blood was sampled for subsequent analyses of melanocortin-1 receptor alleles. ![]() Methods: We studied healthy women with bright red (n=10) or dark (n=10) hair. We thus tested the hypothesis that the requirement for the volatile anesthetic desflurane is greater in natural redhead than in dark-haired women. Furthermore, red hair results from distinct mutations of the melanocortin-1 receptor. There is an anecdotal impression that anesthetic requirement is increased in redheads. Background: Age and body temperature alter inhalational anesthetic requirement however, no human genotype is associated with inhalational anesthetic requirement. ![]()
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